Sunday, December 10, 2023

Ayahuasca and Addiction Recovery: A Novel Approach

Ayahuasca, an Amazonian plant medicine, has long been utilized by indigenous communities for its powerful healing and visionary effects. More recently, however, there has been increasing research interest into potential therapeutic uses for various mental health conditions, including addiction. This report details ayahuasca as an innovative approach for substance abuse recovery alongside scientific evidence supporting its efficacy as well as implications for future treatment approaches for addiction treatment.

A Brief Overview of Ayahuasca

Ayahuasca is a psychoactive brew composed of Banisteriopsis caapi vine and Psychotria viridis plant leaves native to the Amazon rainforest, combined to produce N,N-Dimethyltryptamine (DMT). DMT becomes orally active due to monoamine oxidase inhibitors (MAOIs) present in B. caapi vine; indigenous communities in South America have used Ayahuasca for centuries for spiritual, medicinal, and social purposes.

Ayahuasca and Addiction Recovery

Addiction recovery using Ayahuasca relies on its potential to bring profound psychological and emotional experiences that lead to lasting changes in behavior and mental health. Advocates for Ayahuasca-Assisted Therapy for Addiction state that this brew can assist individuals in confronting the root causes of substance abuse, promote personal insight and self-awareness as well as facilitate emotional healing and growth. Key effects associated with Ayahuasca for Addiction Recovery include:

  • Neuroplasticity: Research indicates that Ayahuasca may promote neuroplasticity – the brain’s capacity for creating new neural connections and adapting to change – which may aid in breaking addiction and maintaining long-term recovery.
  • Emotional Processing: Studies have shown that Ayahuasca can assist with the processing of traumatic memories and unresolved emotions, providing essential therapeutic tools in combatting substance abuse.
  • Spiritual Experiences: Many participants in Ayahuasca ceremonies report profound spiritual experiences, which can create a sense of interconnectivity, greater empathy, and increased purpose – qualities which may aid recovery from addiction.

Scientific Studies on Ayahuasca and Addiction

As Ayahuasca for addiction recovery remains an emerging field, several studies have provided preliminary evidence of its efficacy:

  • 2013 research article published in Current Drug Abuse Reviews showed that individuals with substance use disorders who participated in Ayahuasca-Assisted Therapy experienced significant reductions in substance abuse, improved mental health, and an increase in quality of life.
  • 2016 research article published in the Journal of Psychoactive Drugs demonstrated that participants in an ayahuasca-based addiction treatment program in Brazil experienced decreased substance abuse as well as improvements in measures of depression, anxiety and hopelessness.
  • 2019 qualitative study published in Frontiers in Pharmacology demonstrated that Ayahuasca-Assisted Therapy led to improvements in self-awareness, self-acceptance, craving management and emotional regulation among individuals with histories of substance use disorder.
  • 2022 research study at Cambridge University indicated Ayahuasca was effective for depression with structural changes observed in the medial part of the brain

Note that these studies are preliminary; for definitive proof, further rigorous, controlled research must be conducted on ayahuasca-assisted therapy for addiction recovery.

Considerations and Challenges

Addiction recovery with Ayahuasca may present unique challenges and considerations, including:

  • Safety Issues: Ayahuasca can have harmful side effects when taken in combination with certain medications or by those with preexisting medical conditions, so its safe use in addiction recovery requires thorough screening, preparation, and medical supervision.
  • Legal and Regulatory Concerns: Ayahuasca’s legal standing differs by country and, sometimes, region. In the US, DMT is classified as a Schedule I controlled substance – making its use illegal under most circumstances and creating challenges to developing and implementing AAT programs that limit individual’s access.
  • Cultural Appropriation and Ethical Concerns: With its increasing popularity among Western populations, Ayahuasca-assisted therapy programs must ensure that they operate with cultural sensitivity and respect for traditions they derive from. The use of Ayahuasca for medicine purposes poses particular ethical concerns due to cultural appropriation concerns and any potential exploitation. To avoid any potentially unethical practices from emerging, ensure these therapy programs respect Indigenous knowledge and practices when conducting them.
  • Access and Availability: Access to Ayahuasca-Assisted Addiction Therapy is currently limited, as most programs operate only in countries where its use is legal or tolerable; this may present barriers for individuals unable to travel or who live in areas where Ayahuasca use is banned or restricted.
  • Integration Support: Integrating insights and experiences gained during Ayahuasca sessions is considered a cornerstone of therapy programs using Ayahuasca-assisted therapies. Therefore, providing adequate resources and support for individuals to process and integrate their experiences is crucial to the success of such programs.

Future Directions and Implications

As interest in the therapeutic potential of ayahuasca for addiction recovery continues to expand, several key developments and implications will likely shape its future:

  • Research Advancements: With more rigorous, controlled studies being conducted on ayahuasca-assisted therapy for addiction recovery, evidence supporting its safety and efficacy will likely expand, potentially leading to greater acceptance and integration into mainstream addiction treatment methods.
  • Changes to Law and Regulation: Any modifications in the legal or regulatory landscape surrounding psychedelic substances (like Ayahuasca) could allow greater access to programs for Ayahuasca-Assisted therapy programs and the creation of standardised treatment protocols.
  • Collaborative and Interdisciplinary Approaches: Integrating Ayahuasca-assisted Therapy with other evidence-based addiction treatment modalities such as Cognitive-Behavioral Therapy, Motivational Interviewing, and Mindfulness Based Approaches can create more comprehensive, holistic treatments programs for individuals struggling with substance use disorder.
  • Training and Professionalization: With increasing interest in Ayahuasca-assisted Therapy for Addiction Recovery, training programs and professional standards will likely emerge for practitioners working in this field, to ensure safe and effective administration.

Ayahuasca-assisted therapy represents a promising and novel approach to addiction recovery, with preliminary research suggesting potential benefits in terms of reduced substance use and enhanced mental health outcomes. While challenges and considerations still exist, advances in research, legal reform, interdisciplinary collaborations, and continued advances may help advance and integrate this therapy more broadly into addiction treatment landscape. As our understanding of ayahuasca’s healing potential deepens over time, its healing properties may offer hope and healing for individuals suffering from substance abuse and addiction.


Loizaga-Velder, A., & Verres, R. (2013). Therapeutic Effects of Ritual Ayahuasca Use in the Treatment of Substance Dependence-Qualitative Results. Journal of Psychoactive Drugs, 46(1), 63-72. doi:10.1080/02791072.2013.873157

Thomas, G., Lucas, P., Capler, N. R., Tupper, K. W., & Martin, G. (2013). Ayahuasca-assisted therapy for addiction: Results from a preliminary observational study in Canada. Current Drug Abuse Reviews, 6(1), 30-42. doi:10.2174/15733998113099990003

Nielson, E. M., & Guss, J. (2018). The influence of ayahuasca on mental health and well-being: A qualitative study of participant experiences at a Canadian ayahuasca treatment program. Journal of Psychoactive Drugs, 50(3), 245-255. doi:10.1080/02791072.2018.1442387

Palhano-Fontes, F., Barreto, D., Onias, H., Andrade, K. C., Novaes, M. M., Pessoa, J. A., … & Tófoli, L. F. (2019). Rapid antidepressant effects of the psychedelic ayahuasca in treatment-resistant depression: a randomized placebo-controlled trial. Psychological Medicine, 49(4), 655-663. doi:10.1017/S0033291718001356

European Psychiatry , Volume 65 , Special Issue S1: Abstracts of the 30th European Congress of Psychiatry , June 2022 , pp. S871 – S872

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